What is the meaning of Toxicoderma?
Medical Definition of toxicoderma : a disease of the skin caused by a toxic agent.
Which drugs cause drug eruptions?
Quinines and salicylates can cause type III reactions and topical medications such as neomycin can cause type IV reactions. The most common drugs that may potentially cause drug eruptions include amoxicillin, trimethoprim sulfamethoxazole, ampicillin, penicillin, cephalosporins, quinidine and gentamicin sulfate.
How long does drug induced urticaria last?
Urticaria is classified according to its duration [4]. In acute drug-induced urticaria, weals appear within a few hours to a few days after the administration of the drug. They usually disappear within several days of drug cessation.
What causes drug eruptions?
What causes drug eruptions? Immediate reactions occur within an hour of exposure to the drug and are mediated by IgE antibodies (urticaria, anaphylaxis). Delayed reactions occur between 6 hours and several weeks of first exposure to the drug. They may be mediated by IgG antibody, immune complex, or cytotoxic T cells.
What is Lyell’s syndrome?
Lyell’s syndrome, or toxic epidermal necrolysis, is a rare, potentially life-threatening mucocutaneous disease, usually provoked by the administration of a drug and characterized by acute necrosis of the epidermis.
What does drug rash look like?
Drug rashes can appear as a variety of skin rashes, including pink to red bumps, hives, blisters, red patches, pus-filled bumps (pustules), or sensitivity to sunlight. Drug rashes may involve the entire skin surface, or they may be limited to one or a few body parts. Itching is common in many drug rashes.
How do you treat drug eruptions?
Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive, involving the administration of oral antihistamines, topical steroids, and moisturizing lotions. Severe reactions (eg, SJS, TEN, and hypersensitivity reactions) warrant hospital admission.
Which medicine is best for urticaria?
Antihistamines like Benadryl and Claritin are often effective in relieving the symptoms of urticaria. Taking this type of medication at the first sign of hives can help lessen the severity of the outbreak.
What are the 4 types of hypersensitivity reactions?
In 1963, two British immunologists, Robert Coombs and Philip Gell, classified four different types of hypersensitivity reactions:
- Immediate (type I) Symptoms appear after a few seconds to minutes.
- Cytotoxic (type II)
- Immune complex-mediated (type III)
- Delayed hypersensitivity (type IV)
What is the most common drug induced cutaneous reaction?
Exanthematous drug eruptions, also known as maculopapular drug eruptions, are the most common cutaneous skin reactions and represent approximately 95% of all cutaneous drug eruptions.
Can you survive toxic epidermal necrolysis?
Serious complications can include pneumonia, overwhelming bacterial infections (sepsis ), shock, multiple organ failure, and death. About 10 percent of people with Stevens-Johnson syndrome die from the disease, while the condition is fatal in up to 50 percent of those with toxic epidermal necrolysis.