Which gene is responsible for type 2 diabetes?

Which gene is responsible for type 2 diabetes?

Genes associated with type 2 diabetes risk include: TCF7L2, which affects insulin secretion and glucose production. ABCC8, which helps regulate insulin. CAPN10, which is associated with type 2 diabetes risk in Mexican Americans.

What gene is diabetes found on?

The risk of developing type 1 diabetes is increased by certain variants of the HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system.

How many genes does type 2 diabetes have?

To date, approximately 70 susceptibility genes have been identified as being associated with type 2 diabetes (T2D) at a genome-wide significant level ( ). However, all the genetic loci identified so far account for only about 10% of the overall heritability of T2D.

Is there a genetic test for type 2 diabetes?

Genetic testing for the prediction of type 2 diabetes in high risk individuals is currently of little value in clinical practice.

What is the root cause of type 2 diabetes?

Type 2 diabetes is primarily the result of two interrelated problems: Cells in muscle, fat and the liver become resistant to insulin. Because these cells don’t interact in a normal way with insulin, they don’t take in enough sugar. The pancreas is unable to produce enough insulin to manage blood sugar levels.

Is type 2 diabetes hereditary or acquired?

Type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The risk of developing type 2 diabetes increases with the number of affected family members.

Can you avoid diabetes if it runs in your family?

Even if you have a family health history of diabetes, you can prevent or delay type 2 diabetes by eating healthier, being physically active, and maintaining or reaching a healthy weight. This is especially important if you have prediabetes, and taking these steps can reverse prediabetes.

Are bananas good for a diabetic?

Bananas are a safe and nutritious fruit for people with diabetes to eat in moderation as part of a balanced, individualized diet plan. A person with diabetes should include fresh, plant food options in the diet, such as fruits and vegetables. Bananas provide plenty of nutrition without adding many calories.

Can you make type 2 diabetes go away?

There is no known cure for type 2 diabetes. But it can be controlled. And in some cases, it goes into remission. For some people, a diabetes-healthy lifestyle is enough to control their blood sugar levels.

Is there a gene that causes Type 2 diabetes?

From the WebMD Archives. Oct. 28, 2004 — Specific variations of a gene may cause up to 20% of all type 2 diabetes cases in white people, a finding that could lead to new treatments. The gene called PTPN1 (protein tyrosine phosphatase N1) is found on human chromosome 20, which researchers have long investigated for diabetes genes.

Who is the scientist who discovered type 2 diabetes?

If it is too high, that’s [type 2] diabetes ,” says senior researcher Donald W. Bowden, PhD, a professor of biochemistry at Wake Forest University School of Medicine in Winston-Salem, N.C. His report appears in the November issue of the journal Diabetes.

Where can I learn more about the genetics of diabetes?

If you would like to learn more about the genetics of all forms of diabetes, the National Institutes of Health has published The Genetic Landscape of Diabetes. This free online book provides an overview of the current knowledge about the genetics of type 1 and type 2 diabetes, as well other less common forms of diabetes.

Is the PTPN1 gene responsible for type 2 diabetes?

About 35% of whites have this type 2 diabetes -causing variant of PTPN1; nearly 45% have a protective version of PTPN1. Other variations seem to be neutral, researchers say. The newly discovered variations of the PTPN1 gene are possibly a big contributor to type 2 diabetes among whites — but not the only gene responsible for diabetes.