What is genetic testing for kidney disease?

What is genetic testing for kidney disease?

Renasight is a test to determine if there is a genetic cause for an individual’s kidney disease or if there is an increased hereditary risk due to family history. The test uses a blood or saliva sample to test 385 genes associated with chronic kidney disease (CKD).

Which gene is associated with CKD?

The overall conclusion of this study is that variants in GPX1, GSTO1, GSTO2, UMOD, and MGP genes are associated with CKD. In addition, other genes were found to be associated with CKD related pathologies, such as hypertension (GPX4, CYP11B2, ERCC4), cancer predisposition (ERCC2), and cardiovascular disease (ERCC2).

Is CKD a genetic disease?

Genetic factors are increasingly recognized to contribute to the risk of chronic kidney disease (CKD), and important differences in the risk of progression to end-stage renal disease (ESRD) have been observed in various racial groups (1).

What is GWAS used for?

Genome-wide association studies (GWAS) use high-throughput genomic technologies to scan entire genomes of large numbers of subjects quickly, in order to find genetic variants correlated with a trait or disease.

What is Prospera test?

Covered by Medicare, Prospera is a transplant rejection test that uses a simple blood draw to assess the risk of rejection of a transplanted kidney. Through the use of advanced cell-free DNA technology, Prospera increases a provider’s ability to identify otherwise undetected rejection that might lead to kidney loss.

What is IgA neuropathy?

IgA nephropathy is a chronic kidney disease. It progresses over 10 to 20 years, and it can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the filters (glomeruli) in the kidney.

Can CKD go away?

There’s no cure for chronic kidney disease (CKD), but treatment can help relieve the symptoms and stop it getting worse. Your treatment will depend on the stage of your CKD. The main treatments are: lifestyle changes – to help you stay as healthy as possible.

How long can you live with chronic kidney disease?

Without a transplant, men between the ages of 30 to 35 have a life expectancy of 14 years with stage 5 CKD. For women of the same age, the expected life span is 13 years. If you are between 70 and 75 years, life expectancy is 4 years for both men and women.

Why are GWAS studies important?

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

What is AlloSure test?

The AlloSure test is a clinical-grade, targeted, next generation sequencing (NGS) assay that measures single-nucleotide polymorphisms (SNPs) to accurately quantify donor-derived cell-free DNA (dd-cfDNA) in renal transplant recipients without separate genotyping of either the donor or the recipient.

How is genetic testing used to treat CKD?

Genetic Testing to Understand and Address Renal Disease Disparities (GUARDD) HTN is a risk factor for progression of CKD and for increased cardiovascular risk with CKD. Thus targeting blood pressure control as a modifiable risk factor may both reduce CVD in people with CKD and reduce progression of CKD to end stage disease.

How are genetics and Genomics used in kidney research?

Genetics and genomics approaches to elucidate the normal and pathologic function of the kidney. The Kidney Genetics and Genomics program advances research that uses genetic and genomic approaches to understand the normal and pathologic functions of the kidney.

How is exome sequencing used to diagnose kidney disease?

We conducted exome sequencing and diagnostic analysis in two cohorts totaling 3315 patients with chronic kidney disease. We assessed the diagnostic yield and, among the patients for whom detailed clinical data were available, the clinical implications of diagnostic and other medically relevant findings.

Is there genome wide association study of renal function traits?

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study Am J Nephrol. 2018;47(5):304-316.doi: 10.1159/000488946. Epub 2018 May 18. Authors