Why do African Americans have low renin?

Why do African Americans have low renin?

African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system (RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile.

Should African Americans take losartan?

Losartan may not have as good an effect in people of African-American descent. The dosage of losartan may need reducing in people with liver disease. Should not be used during pregnancy.

Are ARBs effective in African Americans?

More recently, studies with angiotensin receptor blockers (ARBs) have shown blood pressure (BP) response in African Americans that is less than that in whites,[10,11] but this difference was eliminated when ARBs were combined with low-dose diuretics.

Which hypertension medication is best for African American?

Calcium channel blockers, namely amlodipine (Norvasc), or the less often prescribed felodipine, are also recommended as first choice to control blood pressure, specifically in African Americans.

Why can’t African Americans use ACE inhibitors?

Angiotensin converting enzyme (ACE) inhibitors have been avoided as an initial therapeutic option in the treatment of hypertension in African-Americans. A major reason for this has been the widespread perception of clinicians that these agents have poor blood pressure (BP) lowering efficacy in this population.

Is lisinopril good for African American?

However, lisinopril was associated with an increased risk for heart failure (relative risk [RR] for African Americans=1.32; 95% CI, 1.11–1.58) and stroke (RR for African Americans=1.4; 95% CI, 1.17–1.68), and amlodipine was associated with a higher risk of heart failure (RR in African Americans=1.47; 95% CI, 1.24–1.74) …

What is the problem with losartan?

Losartan can cause low blood pressure. Your risk of low blood pressure is increased if you also take diuretics. Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain.

What is the safest BP medicine?

Safe medications to use include methyldopa and potentially some diuretics and beta-blockers, including labetalol.

Is Olmesartan good for African American?

Conclusions: Telmisartan 80 mg combined with HCTZ 12.5 mg is effective and well tolerated in black patients with mild to moderate hypertension, providing greater antihypertensive activity than the corresponding monotherapies.

Which hypertension medication is bad for African American?

African Americans were no more likely than whites to have adverse effects linked to use of ACE inhibitors.

Why do ACE inhibitors not work on African Americans?

The implication that there are inherent biological differences between black people and members of other races has entered blood pressure medication guidance. Black people are labelled “low-renin responders” so are less likely to respond to ACE inhibitors.

Which is better losartan or amlodipine?

In this study amlodipine proved to be more effective than losartan in achieving the primary end point of reducing mean sitting and standing diastolic and systolic blood pressures, although there was no difference in the percentages of each drug in who reached goal pressure at the initial dosages.

What is the role of Raas in renal reabsorption?

Studies have shown that RAAS is involved in neonatal renal tubular sodium reabsorption.

Can a renin angiotensin inhibitor help African Americans?

It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system (RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension.

What’s the normal GFR number for an adult?

in adults, the normal gFR number is more than 90. For more information, see chart on the bottom of page 2. gFR declines with age, even in people without kidney disease. If your GFR is between 60 and 89…

What is the GFR rate for stage D kidney damage?

not present Stage d description g glomerular Filtration Rate gFR)* K Kidney damage (e.g., protein in 90 or above 2 2 K Kidney damage with mild decrease 60 to 89 3 3a M Moderate decrase in gFR 4 45 to 59 3