Is 10mg tamoxifen as effective as 20mg?

Is 10mg tamoxifen as effective as 20mg?

(18) demonstrate that lower doses of tamoxifen (5 mg/day and 10 mg/day) are less effective than the 20 mg/day dose at reducing normal breast cell proliferation, as measured by mitotic index. These data argue against using lower doses of tamoxifen for breast cancer prevention.

How do you take tamoxifen citrate?

Take this medication by mouth with or without food, usually once or twice daily for 5 years, or as directed by your doctor. Daily dosages greater than 20 milligrams are usually divided in half and taken twice a day, in the morning and evening, or as directed by your doctor.

Is tamoxifen and tamoxifen citrate the same?

Tamoxifen is the active ingredient of tamoxifen citrate. Also called Soltamox.

Is 20 mg tamoxifen enough?

For people diagnosed with DCIS, ADH, or LCIS, the treatment is most commonly 5 years of tamoxifen, at a dose of 20 mg per day, after surgery to remove the abnormal cells. Still, like most cancer medicines, both tamoxifen and aromatase inhibitors can cause side effects.

Why you shouldn’t take tamoxifen?

Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.

What is the success rate of tamoxifen?

The tamoxifen group had the longest follow-up period (9.87 years), shortest endocrine therapy duration (3.29 years), and best survival rate (86.1%).

What not eat or drink when taking tamoxifen?

You certainly don’t want to take a medication to reduce breast cancer risk, only to eat or drink something that renders the tamoxifen less effective. The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications.

Why you should not take tamoxifen?

Can you eat oranges when taking tamoxifen?

Tangerines and other citrus peels contain a chemical called tangeretin, which has been shown to reduce the effectiveness of tamoxifen 41. However, the actual flesh of the fruit contains a lot less tangeretin than the peel, so eating moderate amounts of tangerines and other such citrus fruits should be okay.

Can you drink coffee with tamoxifen?

There’s no harm in women being treated with tamoxifen for breast cancer drinking coffee in moderation. However, drinking excessive amounts can cause irritability, insomnia and indigestion.

How often should you take tamoxifen citrate for breast cancer?

For the treatment of estrogen receptor (ER)-positive metastatic breast cancer. 20 to 40 mg PO daily; doses greater than 20 mg per day should be given in divided doses (morning and evening).

How many milligrams of tamoxifen can you take in one day?

Adults—20 milligrams (mg) per day for 5 to 10 years. Children—Use and dose must be determined by your doctor. Adults—20 milligrams (mg) per day for 5 years. Children—Use and dose must be determined by your doctor. Adults—20 milligrams (mg) per day for 5 years.

Are there side effects to taking tamoxifen citrate tablets?

The benefits of Tamoxifen citrate tablets outweigh its risks in women already diagnosed with breast cancer. *Updated long-term follow-up data (median length of follow-up is 6.9 years) from NSABP P-1 study. See WARNINGS, Effects on the Uterus-Endometrial Cancer and Uterine Sarcoma. **See Table 3 under CLINICAL PHARMACOLOGY, Clinical Studies.

Do you need low testosterone treatment with tamoxifen citrate?

If severe damage was done to the HPTA you will not recover and may be in need of low testosterone treatment. Important Note: Many steroid users believe that a good PCT brings about full recovery, but this is a false belief. A PCT that includes Tamoxifen Citrate will stimulate recovery, but it will not end it.