What does estrogen receptor alpha do?

What does estrogen receptor alpha do?

The physiological functions of estrogenic compounds are modulated largely by the estrogen receptors subtypes alpha (ERα) and beta (ERβ). These proteins have actions in the cell nucleus, regulating transcription of specific target genes by binding to associated DNA regulatory sequences.

What are the different types of estrogen receptors?

The estrogen receptor has three subtypes; estrogen receptor α (ERα), estrogen receptor β (ERβ), which belong to nuclear receptors and membrane receptors, such as G protein-coupled estrogen receptor 1 (GPER1, also known as GPR30), which mediate all of estrogens effects, and the expression of each receptor is largely …

Where are the estrogen receptors?

Estrogen receptors (ERs) are members of the superfamily class of nuclear receptors located in either the cell cytoplasm or nucleus and which function as transcription factors (Lovejoy, 2005).

What is the ligand for estrogen?

As a result, Sedlak et al. [84] reported a new series of 17α-(carboranylalkyl)estradiols as ligands for estrogen receptors α and β. Results showed that all of the tested compounds (Figure 14) had estrogenic activity, although none of them were able to fully activate either ER like 17β-estradiol.

Is plant estrogen the same as human estrogen?

“Phyto-” is a Greek root word meaning “plant.” Estrogen is a female hormone that regulates functions in both women and men. Phytoestrogens, though plant-based, function much like animal estrogen in humans. When we eat phytoestrogens, our bodies may respond as if our own estrogen were present.

What happens when estrogen binds to receptor?

When estrogen enters the nucleus, it binds to the estrogen receptor, causing it to pair up and form a dimer. This dimer then binds to several dozen specific sites in the DNA, strategically placed next to the genes that need to be activated.

How can I increase my estrogen receptors?


  1. Soybeans and the products produced from them, such as tofu and miso, are a great source of phytoestrogens . Phytoestrogens mimic estrogen in the body by binding to estrogen receptors.
  2. Flax seeds also contain high amounts of phytoestrogens.
  3. Sesame seeds are another dietary source of phytoestrogens.

What diseases are caused by estrogen?

Given this widespread role for estrogen in human physiology, it is not surprising that estrogen is also implicated in the development or progression of numerous diseases, which include but are not limited to various types of cancer (breast, ovarian, colorectal, prostate, endometrial), osteoporosis, neurodegenerative …

Is estrogen a steroid?

Most other steroid hormones, including the estrogens, are made by the adrenal glands and the gonads [1].

Are oats high in estrogen?

Bread which contains wholegrains, such as flax, rye, wheat, barley or oats, have naturally high levels of lignans, a kind of phytoestrogen, and depending on the concentration in an individual loaf, can be an excellent way to help boost estrogen levels through food.

What does estrogen do in a cell?

Effects on other hormones that stimulate cell division: estrogen can indirectly stimulate cell division by instructing a target cell to make receptors for other hormones that stimulate breast cells to divide. For instance, estrogen affects the receptor levels of a female hormone called progesterone.