What is TMPRSS2 ERG?

What is TMPRSS2 ERG?

TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8).

What is the ERG oncogene?

ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.

What is T2 ERG?

There is also a urine test for T2:ERG, which is the result of a fusion, or translocation, of parts of two different genes, TMPRSS2 and ERG. This translocation is found in approximately half of advanced prostate cancers. Currently, the T2:ERG test is only available at a few academic cancer centers, Dr. Srivastava said.

Why is the ERG gene important?

During development and in adult tissues, ERG is important for proper endothelial cell migration to form blood vessels. ERG directs the transcription of genes for endothelial cell differentiation, development of vasculature [1], and maintenance of hematopoietic stem cells [2].

What is the function of TMPRSS2?

TMPRSS2 activates; or primes, the spike protein domain (a key glycoprotein found on coronaviruses) which leads to the virus fusing to the respiratory epithelia on the cell surface through binding to ACE2. As TMPRSS2 is a serine protease, it primes the spike-domain (S) of SARS-CoV-2 by cleaving as the S1/S2 sites.

What ERG means?

employee resource group
It’s an acronym you should know. ERG stands for employee resource group. Other lesser used terms include affinity groups or business networking groups. Current groups offer much more than mere professional networking opportunities. ERGs can be found in 90% of Fortune 500 companies.

How do you prevent prostate biopsy?

But it’s possible to rule out prostate cancer and eliminate your need for a biopsy through other screening tests, including: digital rectal exam (DRE) free prostate specific antigen (PSA) test. transrectal ultrasound (TRUS)

How does gene fusion occur?

A fusion gene is a hybrid gene formed from two previously independent genes. It can occur as a result of translocation, interstitial deletion, or chromosomal inversion.

What are TMPRSS2 inhibitors?

At cellular level, the trans-membrane protease serine 2 (TMPRSS2) primes the spike protein of human coronaviruses and facilitates cell entry and infection. Camostat mesilate is an inhibitor of TMPRSS2 and has been shown to be a potent antiviral agent against SARS-CoV-2 in vitro and against SARS-CoV-1 in vivo (mice).

What does the term protease mean?

: any of numerous enzymes that hydrolyze proteins and are classified according to the most prominent functional group (such as serine or cysteine) at the active site. — called also proteinase.

What do you mean by 1 ERG work?

: a centimeter-gram-second unit of work equal to the work done by a force of one dyne acting through a distance of one centimeter and equivalent to 10−7 joule.

How is TMPRSS2 ERG fusion gene study in prostate cancer?

In conclusion, these bioinformatics analyses provide novel insights for TMPRSS2:ERG fusion gene study in prostate cancer. Target inhibition of ERG expression could significantly cause cell growth arrest in prostate cancer cells, which could be a potentially valuable target for prostate cancer treatment.

What is the role of Erg in prostate cancer?

Target inhibition of ERG expression could significantly cause cell growth arrest in prostate cancer cells, which could be a potentially valuable target for prostate cancer treatment. However, the precise mechanism of these results remains unclear; therefore, further studies are required. MeSH terms

How many mutations are there in the ERG gene?

There were 272 mutations of the ERG gene identified in the cBioPortal database; among the mutations, 2 missense mutations (R367C and P401H) were regarded as functional mutations (functional impact score >1.938).