Which is the hydrochloride form of nefopam?
Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. The mechanism of action through which nefopam exerts its analgesic effects is, as of yet, largely unknown but may involve inhibition of serotonin, dopamine and noradrenaline reuptake.
How many mg of nefopam are in a 30 mg tablet?
Each coated tablet contains Nefopam Hydrochloride 30 mg. For the full list of excipients, see section 6.1. 3. Pharmaceutical form White to off white, round, biconvex film coated tablets with ‘NFP’ debossed on one side and plain on other side. 4. Clinical particulars
What is the role of nefopam in multimodal analgesia?
Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug used to prevent postoperative pain, primarily in the context of multimodal analgesia. This paper reviews preclinical and clinical studies in which nefopam has been combined with opioids, non-steroidal anti-inflammatory compounds …
Are there any side effects to taking nefopam?
Some opioid painkillers (like codeine, dihydrocodeine and morphine) have similar side effects to nefopam. This means if you take them together you are more likely to get more side effects such as feeling sick, confusion or dizziness.
What kind of pain is nefopam used for?
Nefopam, sold under the brand names Acupan among others, is a painkilling medication. It is primarily used to treat moderate, acuteor chronic pain. It is believed to work in the brain and spinal cord to relieve pain. There it is believed to work via rather unique mechanisms.
What happens if you overdose on nefopam hydrochloride?
Overdose and death have been reported with nefopam, although these events are less common with nefopam than with opioid analgesics. Overdose usually manifests with convulsions , hallucinations , tachycardia, and hyperdynamic circulation.
What was the generic name for nefopam in the 1960s?
In the 1960s, when it was first developed, it had the generic name fenazoxine. ^ a b c d e f g h i j k l m Sanga M, Banach J, Ledvina A, Modi NB, Mittur A (November 2016). “Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers”.