What drugs affect preload and afterload?

What drugs affect preload and afterload?

1) Vasodilators – Drugs that decrease either preload or afterload. a) The major vasodilators used are ACE inhibitors and angiotensin II receptor antagonists, organic nitrates, hydralazine and nitroprusside.

What increases preload and afterload?

Increased aortic pressure, which increases the afterload on the ventricle, reduces stroke volume by increasing end-systolic volume, and leads to a secondary increase in ventricular preload.

Which medications reduce afterload?


  • Vasodilator Agents.
  • Nitroprusside.
  • Hydralazine.
  • Nitroglycerin.
  • Prazosin. Phentolamine.

Do diuretics reduce preload and afterload?

Diuretics induce sodium and water excretion, leading to decreased cardiac preload and wall tension, and an effective decrease of symptomatic pulmonary and systemic congestion.

Which drugs would increase preload?

Preload reducers include NTG (eg, Deponit, Minitran, Nitro-Bid IV, Nitro-Bid ointment, Nitrodisc, Nitro-Dur, Nitrogard, Nitroglyn, Nitrol, Nitrolingual, Nitrong, Nitrostat, Transdermal-NTG, Transderm-Nitro, Tridil) and furosemide (eg, Lasix).

Which drugs increase preload?

What can increase afterload?

The most common pathologic process that increases afterload is systemic hypertension. Other situations that increase afterload include aortic stenosis (including subvalvular and supravalvular), aortic regurgitation and coarctation of the aorta. The afterload can be decreased by any process that lowers blood pressure.

Which medications increase preload?

What do diuretics do to preload and afterload?

Cardiovascular effects of diuretics Through their effects on sodium and water balance, diuretics decrease blood volume and venous pressure. This decreases cardiac filling (preload) and, by the Frank-Starling mechanism, decreases ventricular stroke volume and cardiac output, which leads to a fall in arterial pressure.

What is a normal preload?

The range of LVEDV in this individual over the normal range of LVEDP (4–12 mmHg) can be seen to be ~96–142 mL. Near maximal LVEDV is assumed in this case to be when the LVEDP is ~20 mmHg (vertical line C). Preload reserve can be defined as maximum LVEDV − current LVEDV.

Does morphine decrease or increase preload?

Morphine has been reported to reduce preload, heart rate, and possibly afterload, the net effect of which is a reduction in myocardial oxygen demand. Evidence supporting its use is very limited despite its widespread application. [ 6]

Do diuretics decrease preload or afterload?

Drugs that decrease afterload either by decreasing volume such as diuretics or by decreasing blood pressure including angiotensin converting enzyme inhibitors and nitrates can secondarily decrease preload because less blood is left in the left ventricle after pumping.

Does morphine decrease preload and afterload?

Secondary pharmacological effects of morphine include depressed responsiveness of alpha-adrenergic receptors (producing peripheral vasodilation) and baroreceptor inhibition. In addition, because morphine decreases both preload and afterload, it may decrease myocardial oxygen demand.

What causes decreased preload?

A decrease in preload may be caused by hypovolemia as a result of hemorrhage, surgery, diuresis, dehydration, vomiting and diarrhea. Resulting in a decrease filling time for the heart may also cause it. Consequently, the blood does not have time to enter the heart to be circulated resulting in hypovolemia.