What is biomarker research?
Biomarker Research is an open access, peer-reviewed journal that encompasses all aspects of biomarker investigation. Biomarker Research aims to publish original discoveries, novel concepts, commentaries and reviews related to biomarker investigation from all biomedical disciplines.
How are biomarkers identified?
Biomarkers can be characteristic biological properties or molecules that can be detected and measured in parts of the body like the blood or tissue. They may indicate either normal or diseased processes in the body. Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones.
What are DNA biomarkers?
Biomarkers are molecules that indicate normal or abnormal process taking place in your body and may be a sign of an underlying condition or disease. Various types of molecules, such as DNA (genes), proteins or hormones, can serve as biomarkers, since they all indicate something about your health.
Is blood pressure a biomarker?
Blood pressure as an example of a biomarker that functions as a surrogate.
Is High Blood Pressure a disease?
High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
Where are biomarkers found?
Biomarkers may be produced by the cancer tissue itself or by other cells in the body in response to cancer. They can be found in the blood, stool, urine, tumor tissue, or other tissues or bodily fluids. Notably, biomarkers are not limited to cancer.
Why do we use biomarkers?
Biomarkers are integral to drug development; they’re really critical, because we need to measure the effects of investigational drugs on people during the clinical trials. And the way we do that is to look at their effect on biomarkers.
Is a biomarker a protein?
More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. One example of a commonly used biomarker in medicine is prostate-specific antigen (PSA).
Is BMI a biomarker?
Body mass index as a biomarker for the evaluation of the “Obesity Paradox” among inpatients.
What does biomarker mean?
A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
What is biomarker assay?
Biomarkers assays are becoming increasingly important in clinical development. These assays can be used to aid the selection of a lead candidate and to understand the mechanism of action of a drug, as a surrogate / pharmacodynamics (PD) marker for monitoring clinical efficacy.
What is a nutritional biomarker?
Generally speaking, a nutritional biomarker is a characteristic that can be objectively measured in different biological samples and can be used as an indicator of nutritional status with respect to the intake or metabolism of dietary constituents .
Is nutrition a status?
Nutritional status is the physiological state of an individual, which results from the relationship between nutrient intake and requirements and from the body’s ability to digest, absorb and use these nutrients. The term malnutrition indicates a bad nutritional status.
What is a comparative standard?
Comparative Standards. Comparative standards are reference values from reputable and authoritative sources such as government agencies, independent scientific panels, standards organizations, and scientific and professional organizations.